A rough calculation comparing 2 lines (lead low to 8 or lead low to 10):
Assuming 3-3 breaks (20 combinations, 35.5% chances):
Lead low and cover RHO works in the following cases:
a) Hxx (left) HJ9 (right) (2 combinations)

AKx (left) J9x (right) (2 combinatins)
Lead low to 10 works in a) but fails in b. It also works when:
c) H9x (left) HJx (right) (4 combinations)
Ah! I almost forget to include d) 9xx (left) AKJ (right). Of coz, anyone can pick this up.
Leading low to 10 works for 2 more 3-3 combinations.
Assuming 4-2 breaks (30 combinations, 48 % chances):
Lead low and cover RHO works when:
a) Hx (left) HJ9x (right) (4 combinations)
Oops! You have only 2 entries and can not lead toward your hand thrice. The entry restriction makes you unable to pick this one up. You can just pick up:

xx (left) AKJ9(right) (1 combination)
Not very good.
Lead low to 10 works in b plus:
c) H9 (left) HJxx (right) (2 combinations)
Oops! wrong again. RHO holds HJ76 and you need to lead from dummy a third time to neutralize the power of his spot. You can't pick this one up.
Two lines works equally when the suit is 4-2.
I guess it is now clear that leading low to 10 works better (just ignore those 5-1/6-0 as you probably can't pick them up with only 2 entries).
What does all these analysis prove?
It prove that:
a) I am poor at counting combinations and permutations.

due to entry restriction, you can't deal with 4-2 break effectively.
Since you can't deal with 4-2 breaks, you must concentrate on 3-3 and leading low to 10 stands out a mile when you a) want to take 2 tricks OR

want to maximize your tricks.