We started off playing Recursive Diamond because we both knew it (because of partners in common) and it's goofy and fun. The system picks up a lot of good results on shapely/light/limited major suit openings and natural/intermediate 2-minor openings, but the sequences after the strong artificial 1♦ opening are nothing special. We decided there must be a way to improve our slam bidding after strong hands without sacrificing the rest of the opening structure. Looking at what many of our friends were playing (and methods again that we were both familiar with from other partnerships) we switched to a strong club system with transfer-oriented symmetric relay responses while retaining our 1M/2m opening structure.
The big problem at this point seemed to be that people always bid over our strong club. All this relay stuff we spent so much time perfecting basically never came up in practice, and we ended up in a lot of "guess" auctions at high levels. At this point we considered switching to a two-way club style opening structure, but we didn't want to give up on the relays since they seemed to work so beautifully in bidding practice (and we do occasionally have an unobstructed auction). After a bunch of work to try to hybridize polish club with symmetric relay we came up with something halfway decent and tried it for a while. The problem was, getting to the right spot after people preempt a polish club seemed even more difficult because responder can't bid freely on nine counts in case opener has a weak notrump. Rather than adopt negative free bids (which seems to be what many two-way club players do) which would take us well out of our comfort zone, we decided to give up on the experiment and revert to strong club. After all, plenty of top pairs play a big club, it can't be all bad...
More recently we discovered three issues with symmetric-style relays. One is the previously mentioned "finding the queen" problem. A second was the sequence 1♣(strong)-1♦(neg)-1♥(really strong) which burns a lot of space and also makes it harder to describe the minimum club openers that include hearts. The third was that sometimes the wrong hand seems to be doing the describing and it would be nice to give responder a chance to relay on some hands. After a fair amount of experimenting we decided to switch to AKQ points with direct bids showing "semi-positive up to min GF" and 1♦ being either desperately weak or a slammish GF. This also helps a bit with the "what happens when opponents interfere" issues because responder makes the ambiguous 1♦ call less often (and when he does and then opponents bid, opener usually wants to pass).
Another interesting situation arose when we noticed that in general our results over our (natural intermediate) 2♦ opening seemed to be better than over our (natural intermediate) 2♣. This is kind of weird because we obviously have more space over 2♣. We were playing basically natural bidding over the diamonds and something close to Wei precision over 2♣. We tried a bunch of different relay-based structures over the 2♣ with marginal improvement. After a lot of work, we devised a transfer-based structure that seemed to be excellent, and spent a lot of time in bidding practice perfecting it. Then we played a bunch of real hands, and realized that this structure was so complex (and totally different from anything else in our system) that we couldn't remember it, and scrapped it. Now we play 2M forcing and 2♦ relay (we can remember relays because we use the same relay structure throughout pretty much).

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